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高丽萍 教授

【来源:甘肃省新药临床前研究重点实验室 | 发布日期: | 作者: 】     【选择字号:
       姓 名: 高丽萍
       Name: Liping Gao
       职 务:教授
       Duty: Associate Professor
       E-mail:gaolp@lzu.edu.cn

       一、科研方向
       主要研究活性氧、活性氮和抗氧化剂在人类疾病,特别是在肿瘤和神经退行性疾病中的作用。一个方向是研究肿瘤细胞死亡和药物抗性的分子机制,侧重于肿瘤化疗多药抗性的氧化还原调节;筛选有效的抗癌药物也是研究目标之一。另一个方向是利用体外和体内方法来研究神经退行性疾病的分子机制和筛选有效的神经保护药物。
       Research Interests:
       My research interests are in the role of reactive oxygen species, reactive nitrogen species and  antioxidants in human diseases, especially cancer and neurodegenerative diseases. One area focuses on the molecular mechanism of tumor cell death and drug resistance, especially redox regulation of multidrug resistance in cancer chemotherapy. In addition, screening effective anticancer drug is also one of our goals. The other area focuses on the use of in vitro, ex vivo systems to study the molecular mechanism of neurodegenerative diseases and screening effective neuroprotective drug。

       二、荣誉称号及奖励
       参加甘肃省自然科学基金项目《维生素E和硒对耐药白血病细胞凋亡调控基因及耐药基因表达影响研究》,获2007年度甘肃医学科技奖二等奖。
       参加甘肃省自然科学基金项目《复方沙棘和沙棘籽油对大鼠缺血性脑梗塞的防护作用及其机理探讨》,获2002年度甘肃医学科技奖三等奖。
       honors and awards:
        Participation in the project ‘The effects of Vitamin E and Selenium on expression of apoptotic gene and multidrug resistant gene in leukemia cells’ funded by science and technology department of Gansu province and won the second grade prize from Gansu Medical Association。
        Participation in the project ‘The protection and mechnism of Compound Hippophae rhamnoides L. and Hippophae rhamnoides L.seed oil on ischemic cerebral infarction in rats’ funded by science and technology department of Gansu province and won the third grade prize from Gansu Medical Association。

       三、个人简历
       2004年11月至今       兰州大学基础医学院生物化学与分子生物学研究所。
       2006年2月-2007年6月    台湾长庚大学医学生物技术研究所博士后。
       1999年7月-2004年10月  兰州医学院生物化学和分子生物学教研室。
       2003年12月-2004年3月  日本山形大学分子病理生物化学短期研修。
       2001年9月-2004年6月   兰州大学细胞生物学专业博士研究生。
       1996年9月-1999年6月   兰州医学院药理学专业硕士研究生。
       1993年7月-1996年5月   兰州手扶拖拉机厂职工医院。
       1989年9月-1993年6月   兰州医学院药学院。
       Resume:
       Aug. 2004 ? Present   Associate Professor, Institute for Biochemistry and Molecular Biology, School of Medical Sciences, Lanzhou University。
Feb. 2006 ? Jun. 2007     Post-doctoral fellow   Graduate Institute of Medical Biotechnology and Department of Medical Biotechnology and Laboratory Science, Chang Gung   University, Taiwan。  
       Jul. 1999 ? Oct. 2004   Associate Professor, Instructor    Department of Biochemistry and Molecular Biology, Lanzhou Medical College
       Sept. 2001 ? Jun. 2004   Ph. D  Cell Biology   School of Life Sciences, Lanzhou University。
       Dec. 2003 ? Mar. 2004    Visiting Scholar   Department of Molecular and Pathological Biochemistry, School of Medicine, Yamagata University, Japan
       Sept. 1996 ? June 1999    M.S  Pharmacology   Department of Pharmacology, Lanzhou Medical College。
       July 1993 ? May 1996   Apothecary   Hospital of Lanzhou tractor factory, Lanzhou。
       Sept. 1989 ? June 1993    B. S.  Pharmacy   Department of pharmacy, Lanzhou Medical College。

       四、发表论文
       SHUUAI Xue-hong, HU Ting-jun, CHEN Jiong-ran, GAO Liping Immune function and antioxidant capability in mice. Acta Veterinaria et Zootechnica Sinica. 2008, 39(7):1000-1004。
       Liping Gao, Chengshang Yuan,  Zhongjian Jia,  Hulai Wei, Rongliang Zheng   Protective effects of verbascoside on hydrogen peroxide-induced cytotoxicity and apoptosis in astrocytes. Progress In Biochemistry and Biophysics. 2008, 35(Suppl): 210-211。
       Gao Liping, Wei Hulai, Jing Tao, Wu Yongjie, Chen Jing, Sun Jing, Yi Juan , Zhao Huaishun.   siRNAs silence expression of mdr1 gene and reverse drug-resistance in K562/ADM cells  China Oncology  2007, 17(1): 58-61。
       Wei Hulai, Gao Liping, Jing Tao, Zhao Huaishun, Yi Juan, Sun Jin, Han Jian.   siRNA silences mdr1 gene expression and reverses apoptosis resistance of K562/ADM cells line. Chinese Journal of Hematology.  2007, 28(6): 388-390。
       Wei Hulai, Zhang Zhewen, Gao Liping, Li Linjing, Yi Juan, Sun Jing.   Kappa-selenocarrageenan overcomes apoptosis resistance in multidrug-resistant K562/ADM cells bydown-regulating expression of mdr1 gene and its product P-glycoprotein. Journal of Modern Oncology. 2006 14(12): 1489-1492。
       DONG Jian-yong,JIA Zhong-jian, GAO Li-ping   Effects of Flavonoids from Hypericum Attemuatum on oxidative stress injury of PC12 cell DNA. Shanghai Journal of Traditional Chinese Medicine. 2006, 40(12):68-70。
       Gao LP, Wei HL, Zhao HS, Xiao SY, Zheng RL.   Antiapoptotic and antioxidant effects of rosmarinic acid in astrocytes. Pharmazie. 2005, 60(1): 62-65。
       Zhang Wenbin, Cheng Tijuan, Gao Liping.   Protective effect of compound hippophae rhamnoids L.granule on ischemic injury in cultured rat cortical neurons. Chinese Journal of clinical Pharmacology Therapeutics. 2004, 9 (2): 189-192。
       Gao Liping, Cheng Tijuan, Wang Yibin, Sun Yifang, Zhang Jian.   The preventive function of compound Hippophae rhamnoides L.against ischemic cerebral infarction in rats and mice. Journal of Lanzhou University (Natural Sci.). 2003, 3 (39): 53-56。
       Cheng Tijuan, Wang Yibin, Gao Liping, Sun Yifang, Zhang Jian.   The protection of seed oil of Hippophae rharmnoides on ischemic cerebral infarction in Rats. China Journal of Chinese Materia Medica. 2003, 6 (28): 548-550。
       Zhang Jun, Hua Yan, WangYuping, Gao Liping, Wei Huilai.   Antioxidant action of Apigenin-quercetin-3, 3’-dimethyl etherhe and quercetagetin-3,6-dimethyl ether-7-o-glucoside in vitro. Pharmacology and Clinics of Chinese Material Medica.  2003, 19 (4): 12-13。
       Gao Liping, Cheng Tijuan, Yang Zhiyong, Sun Yifang.   The influence of compound Hippophae rhamnoides L.on MDA of brain, blood coagulation time and platelet number in focal cerebral ischemia rat.  Pharmacology and Clinics of Chinese Material Medica.  2002, 18 (4): 26-28。
       Yang Zhiyong, Cheng Tijuan, Gao Liping, Liu Guoqing.   The comparative studies between S. przewalsii maxim and S. miltiorrhize on focal cerebral ischemia and blood rheology of rats. Pharmacology and Clinics of Chinese Material Medica.  2002, 18 (6): 26-28。
       Cheng Tijuan, Gao Liping, Wang Yibin, Sun Yifang, Zhang Jian, Li Dongyu.   The effect of seed oil of Hippophae rhamnoides L. (SOHR) on hemorrheology of cerebral infarction in rats.  Pharmacology and Clinics of Chinese Material Medica.  2002, 18(2): 14-15。
       Cheng Tijuan, Gao Liping, Wang Yubin, Sun Yifang, Zhang Jian, Li Dongyu.   The influence of seed oil of Hippophae rhamnoides L.on MDA of brain, blood coagulation time and platelet number in focal cerebral ischemia rat.  Journal of Lanzhou University. 2002, 38 (Suppl): 101-103。

    

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