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达朝山 教授

【来源:甘肃省新药临床前研究重点实验室 | 发布日期: | 作者: 】     【选择字号:

达朝山

教授、博士生导师

联系方式: 

Tel: 0931-8915208

Fax: 0931-8915208

E-mail: dachaoshan@lzu.edu.cn

个人简历

1986年9月至1990年6月,兰州大学生物系植物生理专业,理学学士学位。

1990年6月至1997年8月,甘肃省科学院生物研究所。

1997年9月至2000年6月,兰州大学生命科学学院生物化学与分子生物学系,硕士研究生,理学硕士学位。

2000年9月至2003年6月,兰州大学生命科学学院生物化学与分子生物学研究所,博士研究生,理学博士学位。

2000年7月至今,在兰州大学生命科学学院生物化学与分子生物学研究所从事教学与科研工作。
研究方向
主要从事手性药物与多肽合成法放学研究。我们研究组现在的兴趣主要集中于:(1)手性药物的绿色与原子经济性相关的不对称催化合成方法学研究;(2)不对称格式反应合成手性药物及其中间体;(3)高级结构相关酶模拟物的合成与催化活性研究。
所获奖励:
2008年,甘肃省自然科学奖一等奖(排名第三)。
发表文章:
1.   Ma, Xiao; Da, Chao-Shan*; Yi, Lei; Jia, Ya-Ning; Guo, Qi-Peng; Che, Li-Ping; Wu, Feng-Chun; Wang, Jun-Rui; Li, Wei-Ping. Highly efficient Primary Amine Organocatalysts for the direct asymmetric aldol reaction in brine. Tetrahedron: Asymmetry 2009, 20, 1419-1424.
2.         Wu, Feng-Chun; Da, Chao-Shan*; Du, Zhi-Xue; Guo, Qi-Peng; Li, Wei-Ping; Yi, Lei; Jia, Ya-Ning; Ma, Xiao. N-Primary-Amine-Terminal β-Turn Tetrapeptides as Organocatalysts for Highly Enantioselective Aldol Reaction. J. Org. Chem. 2009, 74, 4812-4818.

3.         Jia, Ya-Ning; Wu, Feng-Chun; Ma, Xiao; Zhu, Gong-Jian; Da, Chao-Shan*. Highly efficient prolinamide-based organocatalysts for the direct asymmetric aldol reaction in brine. Tetrahedron Lett. 2009, 50, 3059-3062.

4.         Da, Chao-Shan*; Che, Li-Ping; Guo, Qi-Peng; Wu, Feng-Chun; Ma, Xiao; Jia, Ya-Ning.  2,4-Dinitrophenol as an effective cocatalyst: greatly improving the activities and enantioselectivities of primary amine organocatalysts for asymmetric aldol reactions.  J. Org. Chem. 2009, 74, 2541-2546.

5.         Yang, Ren-Yong; Da, Chao-Shan*; Yi, Lei; Wu, Feng-Chun; Li, Hong. Asymmetric conjugate addition of unmodified propionaldehyde to β-nitrostyrenes catalyzed by readily available proline-based dipeptidols. Lett. Org. Chem. 2009, 6, 44-49.

6.         Li, Hong; Da, Chao-Shan*; Xiao, Yu-Hua; Li, Xiao; Su, Ya-Ning. Direct Asymmetric Aldol Reaction of Aryl Ketones with Aryl Aldehydes Catalyzed by Chiral BINOL-Derived Zincate Catalyst. J. Org. Chem. 2008, 73, 7398-7401.

7.         Han, Zhi-jian; Da, Chao-shan; Qiu, Li; Ni, Ming; Zhou, Yi-feng; Wang, Rui.  The natural amino acid derived chiral sulfonamide ligands in the catalytic asymmetric addition of phenylacetylene to aldehydes. Lett. Org. Chem. 2006, 3, 143-148.

8.         Da, Chao-shan*; Ni, Ming; Han, Zhi-jian; Yang, Fan; Wang, Rui.  Novel non-azacyclo 1,2-amino alcohols derived from phenylalanine and highly enantioselective addition of diethylzinc to aryl aldehydes. J. Mol. Catal. A: Chem. 2006, 245, 1-7.

9.         Ni, Ming; Wang, Rui; Han, Zhi-jian; Mao, Bin; Da, Chao-shan; Liu, Lei; Chen, Chao.  Synthesis of new C2-symmetrical bissulfonamide ligands and application in the enantioselective addition of alkynylzinc to aldehydes and ketones. Adv. Synth. Catal. 2005, 347, 1659-1665.

10.     Han, Zhi-jian; Da, Chao-shan; Xu, Zhao-qing; Ni, Ming; Wang, Rui. The asymmetric addition of phenylacetylene to aldehydes catalyzed by L-leucine derived chiral sulfonamide alcohol ligands. J. Mol. Catal. A.: Chem. 2005, 236, 32-38.

11.     Kang, Yong-feng; Wang, Rui; Liu, Lei; Da, Chao-shan; Yan, Wen-jin; Xu, Zhao-qing.  Enantioselective alkynylation of aromatic aldehydes catalyzed by new chiral oxazolidine ligands. Tetrahedron Lett. 2005, 46, 863-865.

12.     Da, Chao-Shan; Xin, Zhuo-Qun; Xiao, Yi-Nan; Wang, Heng-Shan; Su, Wu; Yang, Fan; Wang, Rui.  新的含大体积取代基的β-氨基醇配体的合成及在二乙基锌对芳香醛的不对称加成反应中的应用, 有机化学 2004, 24, 943-945.

13.     Zhou, Yi-feng; Wang, Rui; Xu, Zhao-qing; Yan, Wen-jin; Liu, Lei; Gao, Yan-feng; Da, Chao-shan. Boc-L-proline as a new chiral ligand for enantioselective phenylacetylene addition to aromatic aldehydes. Tetrahedron: Asymmetry 2004, 15, 589-591.

14.     Xu, Zhaoqing; Wang, Rui; Xu, Jiangke; Da, Chao-shan; Yan, Wen-jin; Chen, Chao.  Highly enantioselective addition of phenylacetylene to aldehydes catalyzed by a β-sulfonamide alcohol-titanium complex. Angew. Chem., Int. Ed. 2003, 42, 5747-5749.

15.     Wang, Heng-Shan; Da, Chao-Shan; Xin, Zhuo-Qun; Su, Wu; Xiao, Yi-Nan; Liu, Da-Xue; Wang, Rui.  Enantioselective conjugate addition of diethylzinc to chalcone catalyzed by Ni(acac)2 and chiral β-amino alcohols. Chin. J. Chem. 2003, 21, 1105-1107.

16.     Da, Chao-Shan; Wei, Jie; Dong, Shou-Liang; Xin, Zhuo-Qun; Liu, Da-Xue; Xu, Zhao-Qin; Wang, Rui. Highly catalytic enantioselective epoxidation of enones with weak base bicarbonate and hydrogen peroxide. Synth.Commun. 2003, 33, 2787-2792

17.     Da, Chao-shan; Han, Zhi-jian; Ni, Ming; Yang, Fan; Liu, Da-xue; Zhou, Yi-feng; Wang, Rui.  A convenient synthesis of piperidine-based β-amino alcohols from l-Phe and highly enantioselective addition of diethyl zinc to aldehydes. Tetrahedron: Asymmetry 2003, 14, 659-665.

18.     Xin, Zhuo-qun; Da, Chao-shan; Dong, Shou-liang; Liu, Da-xue; Wei, Jie; Wang, Rui.  A novel method for the synthesis of (R)-2,2'-dihydroxy-1,1'-binaphthyl-3,3'-dicarboxylic acid by asymmetric oxidative coupling of a chiral β-naphthol derivative catalyzed by CuCl. Tetrahedron: Asymmetry 2002, 13, 1937-1940.

19.     Liu, Da-Xue; Zhang, Li-Cheng; Wang, Quan; Da, Chao-Shan; Xin, Zhuo-Qun; Wang, Rui; Choi, Michael C. K.; Chan, Albert S. C. The application of chiral aminonaphthols in the enantioselective addition of diethylzinc to aryl aldehydes. Org. Lett. 2001, 3, 2733-2735.

20.     刘大学,汪权,张立臣,达朝山,王锐, 手性联萘酚锂盐催化下三甲基硅氰与芳香醛的对映选择加成反应研究, 高等学校化学学报 200122601-602. (CAJ)

21.     Yang, X.-W.; Shen, J.-H.; Da, Chao-Shan; Wang, H.-S.; Su, W.; Liu, D.-X.; Wang, R.; Choi, M. C. K.; Chan, A. S. C. Highly enantioselective addition of diethylzinc to aldehydes catalyzed by a new chiral C2-symmetric Ti-diol complex. Tetrahedron Lett. 2001, 42, 6573-6575.

22.     粟武,王恒山,达朝山,王锐, 光活性1,1'-联萘酚(BINOL)的不对称合成, 高等学校化学学报 2000211408-1409. (CAJ)

23.     王恒山,杨晓武,粟武,刘大学,达朝山,王锐, 树脂固定化手性联萘酚2钛催化剂的合成及其催化特性研究, 高等学校化学学报 2000211524-1525. (CAJ)

24.     Yang, Xiaowu; Su, Wu; Liu, Daxue; Wang, Hengshan; Shen, Jianheng; Da, Chaoshan; Wang, Rui; Chan, Albert S. C. Preparation and application of polymer-grafted Ti-BINOL complexes as chiral catalysts in the enantioselective addition of diethylzinc to aldehydes. Tetrahedron 2001, 56, 3511-3516.

25.     Wang, R.; Da, Chao-Shan; Liu, D. X.; Yang, X. W.; Xin, Z. Q.; Dong, S. L.; Shen, J. H.; Su, W.; Wang, H. S.; Wang, Q.; Zhang, L. C.; Chan, A. S. C., Highly Catalytic Enantioselective Addition of Diethyl Zinc to Aldehydes and Chalcone in the Presence of Chiral Ligand, Chem. Res. Chin. Univ. 2001, 17(sup), 140-141.

26.     Yang, Xiao-Wu; Sheng, Jian-Heng; Da, Chao-Shan; Wang, Heng-Shan; Su, Wu; Wang, Rui; Chan, Albert S. C.  Polymer-Supported BINOL Ligand for the Titanium-Catalyzed Diethylzinc Addition to Aldehydes: A Remarkable Positive Influence of the Support on the Enantioselectivity of the Catalyst. J. Org. Chem. 2000, 65, 295-266.

27.       Yang, Xiaowu; Shen, Jianheng; Da, Chaoshan; Wang, Rui; Choi, Michael C. K.; Yang, Liwei; Wong, Kwok-yin. Chiral pyrrolidine derivatives as catalysts in the enantioselective addition of diethylzinc to aldehydes. Tetrahedron: Asymmetry 1999, 10, 133-138.

 
参编书籍


达朝山,
王 锐,《不对称有机反应——高效手性配体的设计合成及其在二乙基锌对醛的不对称加成反应中的应用》pp 275-291; 李月明、范青华、陈新滋主编化学工业出版社20051月第一版

地址:甘肃省兰州市东岗西路199号 邮编:730000
电话:0931-8915098 8915890 电子邮箱:xylcq@lzu.edu.cn