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董守良 教授

【来源:甘肃省新药临床前研究重点实验室 | 发布日期: | 作者: 】     【选择字号:

董守良 

教授、博士生导师          

电话:0086-931-8912428

传真:0086-931-8912428       

地址:天水南路222号,兰州大学生命科学学院生物化学与分子生物学研究所

邮编:730000

E-mail:dongsl@lzu.edu.cn     

个人简历

1991.9-1995.6, 兰州大学生物系,本科;

1995.9-1998.6, 兰州大学生物系,硕士;

1998.9-2001.6, 兰州大学生命科学学院,博士;

2001.7-至今, 兰州大学生命科学学院, 教师;

2003.11-2004.12,德国马克斯-普朗克生物化学研究所,生物有机系,访问学者

2004.5-至今, 兰州大学生命科学学院, 副教授;

2007.3-2007.12,德国马克斯-普朗克生物化学研究所, 分子生物技术研究组(生物膜系)、马克斯-普朗克高分子所,客座学者;

2008.3-2008.9,德国马克斯-普朗克生物化学研究所, 分子生物技术研究组(生物膜系),客座学者.

科研方向

1. 生物有机化学

    优化经典有机化学反应,使其应改用于生物大分子的标记和改造等。

2. 生物活性肽的化学改造和生理药理学检定

    使用非天然氨基酸或者化学键代替原始氨基酸或者肽键,设计并合成新型生物活性多肽,使之具备比母体更好的活性和持久的药物时间。

3. 生物物理学及计算生物学

    计算机辅助药物设计和生物分子的模拟、核磁结构解析,分子对接等。
荣誉称号及奖励:                                                       
1. 德国克虏伯基金会中国青年学者奖(2003

2. 甘肃省精品课程/一等奖/甘肃省教育厅/2003/(3/3)

3. 教育部理科基地名牌课程/一等奖/教育部/2002/(2/3)

4. 内吗啡肽2类似物EM-2(Ala4-NH-Bn)的合成及其镇痛活性研究,挑战杯一等奖;2002

5. 神经肽类似物的设计合成、溶液构象和生物活性,教育部科技成果鉴定(2001, 第三完成人)

6. 甘肃省科技进步三等奖2001(2/10);

7. 甘肃省科技进步二等奖1999(7/10);

8. 中国化学会会员;

9. 中国生物化学与分子生物学学会会员;

10. 中国生理学学会会员

论文

2011

48. Tobias E. Schrader,Thorben Cordes,Wolfgang J. Schreier,Florian O. Koller, Shou-Liang Dong, Luis Moroder, Wolfgang Zinth (2011). Folding and Unfolding of Light-Triggered β-Hairpin Model Peptides. J. Phys. Chem. B. DOI: 10.1021/jp107683d.

47. Jing Wang, Li Wang, Meixing Li, Qiaoying Jin, Shouliang Dong* (2011). Preliminary analgesic properties of deltorphin-5-methoxytryptamine chimeric opioid peptides. Peptides. doi:10.1016/j.peptides.2011.01.032.

2010

46. ChunnanWei, Wenmin Huang, Xiaoting Xing and Shouliang Dong*(2010). Dual effects of [Tyr6]-γ2-MSH(6–12) on pain perception and in vivo hyperalgesic activity of its analogues. J. Pept. Sci. 16, 451-455. DOI 10.1002/psc.1255 (SCI)

45. Sha-Sha Wang, Yu-Ling Zeng, Wen-Wei Zhang, Shou-Liang Dong* (2010). A snake venom peptidewith the contrary effect on rat stomachfundus and guinea pig ileum. Pharmazie. 65: 383–385. doi: 10.1691/ph.2010.9683 (SCI)

44. Yinliang Yang, Zhongqiu Ni, Shouliang Dong * (2010), Effects of Endokinin A/B and Endokinin C/D on the antinociception of Endomorphin-1 in mice. Effects of Endokinin A/B and Endokinin C/D on the antinociception of Endomorphin-1 in mice. Peptides, 31(4): 689-695. doi:10.1016/j.peptides.2009.12.022 (SCI)

43. Zhiyuan Cong, Yun Huang, Longfei Yang, Dan Ye, Shouliang Dong*(2010), Solution structure of a photo-switchable insect kinin thioxo-analog. Protein & Peptide Letters. 17(3): 343-346 (SCI)

42. 张 波, 丛志远, 杨银亮, 杨龙飞, 董守良* (2010) . 昆虫激肽的生理功能及机制. 生命的化学. 30(1): 42-45.

41. Zhiyuan Cong, Longfei Yang, Ling Jiang, Dan Ye, Shouliang Dong* (2010). Comparison of two thioxopeptide bond photoswitches in insect kinin. Chinese Chemical Letters. 21(4): 476-479. doi:10.1016/j.cclet.2009.12.033 (SCI)

40. Hong Kui, Huiying Luo, Pengjun Shi, Yingguo Bai, Tiezheng Yuan, Yaru Wang, Peilong Yang, Shouliang Dong, Bin Yao (2010). Gene Cloning, Expression, and Characterization of a Thermostable Xylanase from Nesterenkonia xinjiangensis CCTCC AA001025. Appl Biochem Biotechnol. 162(4):953-65. DOI 10.1007/s12010-009-8815-5 (SCI)

39. Yinliang Yang, Shouliang Dong* (2010). Effects of Endokinin A/B and Endokinin C/D on the modulation of pain in mice. Peptides. 31(1), 94-100. doi:10.1016/j.peptides.2009.10.013 (SCI)

38. Guohua Lv, Shouliang Dong* (2010). Solution Structural Investigation and Conformation-Activity Relationship of BAM8-22 by NMR and Molecular Dynamics Simulations. Bioorganic & Medicinal Chemistry Letters. 20(3), 1260-1262. doi: 10.1016/j.bmcl.2009.11.110 (SCI)

2009

37. Shouliang Dong, Luis Moroder, Nediljko Budisa (2009). Protein Iodination by Click Chemistry. ChemBioChem, 10, 1149-1151. DOI: 10.1002/cbic.200800816 (SCI)

36. 马国宁, 董守良* (2009). 阿片肽样嵌合肽. 生命的化学. 29(3), 414-417.

2008

35. Huang, Y., Cong, Z., Yang, L., and Dong, S*. (2008) A photoswitchable thioxopeptide bond facilitates the conformation-activity correlation study of insect kinin, J Pept Sci 14, 1062-1068. (SCI)

34. Dong, S., Merkel, L., Moroder, L., and Budisa, N. (2008) Convenient syntheses of homopropargylglycine, J Pept Sci 14, 1148-1150. (SCI)

33. Li Zhao, Lanxia Zhou, Baohong Zhang, Xiang Yan, Juan Li, Yali Peng, Min Chang, Shouliang Dong, Rui Wang (2008), Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell, Pharmazie, 63: 676-685. (SCI)

32. Dong, S.L., Merkel, L., Musiol, H.J., Budisa, N. and Moroder, L. (2008). Advances in the stereoselective synthesis of homopropargylglycine. J. Peptide Sci. 14 (8), 49-49.

31. 金莲,刘鑫,王锐,董守良* (2008),神经介素B 受体与拮抗剂、激动剂的分子模拟研究,化学学报20082271-2278. (SCI)

30. 杨丹,董守良* (2008),人体激肽释放酶2与前列腺癌,生命的化学731-736. (CSCD)

2007

29. Zinth, W., Schrader, T. E., Schreier, W. J., Koller, F. O., Cordes, T., Babitzki, G., Denschlag, R., Tavan, P., Loweneck, M., Dong, S. L., Moroder, L., and Renner, C. (2007) Ultrafast unzipping of a beta-hairpin peptide, Ultrafast Phenomena Xv 88, 498-500. (SCI)

28. Yu, Y., Shao, X., Cui, Y., Liu, H., Wang, C., Fan, Y., Liu, J., Dong, S., and Wang, R. (2007) Structure-activity study on the spatial arrangement of the third aromatic ring of endomorphins 1 and 2 using an atypical constrained C terminus, Chemmedchem 2, 309-317. (SCI)

27. Schrader, T. E., Schreier, W. J., Cordes, T., Koller, F. O., Babitzki, G., Denschlag, R., Renner, C., Loweneckt, M., Dong, S. L., Moroder, L., Tavan, P., and Zinth, W. (2007) Light-triggered beta-hairpin folding and unfolding, Proceedings of the National Academy of Sciences of the United States of America 104, 15729-15734. (SCI,综合一区)

26. Dong, S. L., Cadamuro, S. A., Fiorino, F., Bertsch, U., Moroder, L., and Renner, C. (2007) Copper binding and conformation of the N-terminal octarepeats of the prion protein in the presence of DPC micelles as membrane mimetic, Biopolymers 88, 840-847. (SCI)

25. 周兰霞,金莲,赵丽,孟雪琴,董守良*ArcGIS910在苯丙酮尿症空间分析中的应用,中国卫生统计200724604-606 (CSCD)

2006

24. Peng, Y. L., Chang, M., Dong, S. L., Li, W., Han, R. W., Fu, G. X., Chen, Q., and Wang, R. (2006) Novel potent agonist (pF)Phe(4),Aib(7) Aib(11),Arg(14),Lys(15) N/OFQ-NH2 and antagonist Nphe(1),(pF)Phe(4),Aib(7),Aib(11),Arg(14),Lys(15) N/OFQ-NH2 Of nociceptin/orphanin FQ receptor, Regulatory Peptides 134, 75-81. (SCI)

23. Loeweneck, M., Dong, S.-L., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. (2006) A photo-controlled beta-hairpin, Understanding Biology Using Peptides, 36-37. (ISTP)

22. Dong, S. L., Loweneck, M., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. (2006) A photocontrolled beta-hairpin peptide, Chemistry-a European Journal 12, 1114-1120. (SCI,化学二区)

2005

21. Musiol, H.-J., Dong, S., Kaiser, M., Bausinger, R., Zumbusch, A., and Moroder, L. (2005) Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins, Peptides 2004, Proceedings:BRIDGES BETWEEN DISCIPLINES, 595-596. (ISTP)

20. Musiol, H. J., Dong, S. L., Kaiser, M., Bausinger, R., Zurnbusch, A., Bertsch, U., and Moroder, L. (2005) Toward semisynthetic lipoproteins by convergent strategies based on click and Ligation chemistry, Chembiochem 6, 625-628. (SCI,生物二区)

19. Musiol, H. J., Dong, S. L., Kaiser, M., Bausinger, R., Zumbusch, A., and Moroder, L. (2005) Click and ligation chemistry for the synthesis of GPI-anchored membrane proteins, Peptides 2004, Proceedings, 595-596. (ISTP)

18. Loeweneck, M., Dong, S. L., Schrader, T. E., Schreier, W. J., Zinth, W., Moroder, L., and Renner, C. (2005) A photo-controlled beta-hairpin, Biopolymers 80, 547. (SCI, abstract)

17. Chang, M., Peng, Y. L., Dong, S. L., Han, R. W., Li, W., Yang, D. J., Chen, Q., and Wang, R. (2005) Structure-activity studies on different modifications of nociceptin/orphanin FQ: Identification of highly potent agonists and antagonists of its receptor, Regulatory Peptides 130, 116-122. (SCI)

16. 刘鑫,董守良* (2005). 胸腺5肽同其受体结合的分子模型. 中国生物化学与分子生物学会第九届会员代表大会及全国学术会议论文摘要. p86

15. 彭雅丽,常民,李威,韩仁文,付国兴,董守良,王锐. (2005) 孤啡肽N末端修饰类似物的构效关系研究. 中国生物化学与分子生物学会第九届会员代表大会及全国学术会议论文摘要. p94

14. 常民,彭雅丽,韩仁文,李威,付国兴,董守良,王锐. (2005) 孤啡肽不同修饰的构效关系研究:孤啡肽受体激动剂和拮抗剂的检定. 中国生物化学与分子生物学会第九届会员代表大会及全国学术会议论文摘要. p145

2004

13. Shouliang Dong, Tao Wang, Bangzhi Zhang, Jie Wei, and Rui Wang. Synthesis and hypotensive activity of [Tyr1]NC(1-13)NH2, an analog of nociceptin. in Peptides, Biology and Chemistry, Eds, Yu-cang Du, You-shang Zhang, James P. Tam (2004). 189-191.

2003

12. Da, C. S., Wei, J., Dong, S. L., Xin, Z. Q., Liu, D. X., Xu, Z. Q., and Wang, R. (2003) Highly catalytic enantioselective epoxidation of enones with weak base bicarbonate and hydrogen peroxide, Synthetic Communications 33, 2787-2792. (SCI)

11. 李仁德,董守良,陈强. (2003) 人体及动物生理学实验指导. 兰州大学出版社.

2002

10. Xin, Z. Q., Da, C. S., Dong, S. L., Liu, D. X., Wei, J., and Wang, R. (2002) A novel method for the synthesis of (R)-2,2 '-dihydroxy-1,1 '-binaphthyl-3,3 '-dicarboxylic acid by asymmetric oxidative coupling of a chiral beta-naphthol derivative catalyzed by CuCl, Tetrahedron-Asymmetry 13, 1937-1940. (SCI)

9. Zheng-Ping Jia, Shou-Liang Dong, Xiao-Wu Yang, Bang-Zhi Zhang Xiao-Li Wang and Rui Wang. (2002) Anticancer pharmacology of actinomycin D and its analogs. In Peptides, Biology and Chemistry. Eds, James P. Tam. P198-201

  2000

8. Shou-liang Dong, Rui Wang, Tao Wang and Xiao-yu Hu. (2000) The synthesis and opioid activities of nociceptin and its fragments. In Peptides, Biology and Chemistry. Eds, Xiao-yu Hu, Rui Wang, James P. Tam. P95-97

7. Rui Wang, Tao Wang, Shou-Liang Dong, Qiang Chen and Xiao-Yu Hu. (2000) Hypotensive activities of nociceptin and its fragments. In Peptides, Biology and Chemistry. Eds, Xiao-yu Hu, Rui Wang, James P. Tam. P108-109

6. 陈强; 陈勇; 陈鲤翔; 杨顶建; 董守良; 王锐; (2000) 痛稳素的合成及其对血管活性的影响, 科学通报452620-2625 (SCI)

1999

5. 董守良,王涛,陈强,王锐. (1999) 孤啡肽及其片段的合成和构效关系. 科学通报441296-1300 (SCI)

4. 董守良, 王 涛, 陈 强, 王 锐. (1999) 孤啡肽及其片段的合成、痛觉调节作用和对免疫功能的影响. 药学学报34669-672 (CSCD)

3. 董守良,王 涛,王 锐. (1999) 孤啡肽研究进展. 中国药理学通报15300-303 (CSCD)

1998

2. 董守良,倪京满,王 勤,王 锐. (1998) 放线菌素D 及类似物对荷瘤小鼠生理生化影响. 兰州大学学报34137-138 (CSCD)

1997

1. WANG R, NI J, HU X, MA Y, LI X, YANG D, DONG S, YANG X, and PAN X. (1997) Synthesis and DNA-binding ability of Spl protein zinc finger domain and its peptidomimetics. Science in China, Ser. C, 5, 518-523

地址:甘肃省兰州市东岗西路199号 邮编:730000
电话:0931-8915098 8915890 电子邮箱:xylcq@lzu.edu.cn