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张邦治 副教授

【来源:甘肃省新药临床前研究重点实验室 | 发布日期: | 作者: 】     【选择字号:

张邦治 

职务:副教授

电话:0931-8915522

传真:0931-8915522

 

E-mail: zhangbz@lzu.edu.cn            

                                         

科研方向      

1、多肽药物的设计与合成                                                  

2抗肿瘤多肽药物的构效关系、生理药理活性和作用机制研究                                                     

 

荣誉称号及奖励

 

甘肃省自然科学一等奖,2008                                                      

 

个人简历  

 

张邦治,男,1977年生,副教授。

1999年于兰州大学生命科学学院生物化学专业获学士学位,

2005年于兰州大学生命科学学院生物化学与分子生物学专业获博士学位,

2005至2010年任兰州大学生命科学学院讲师。

 

主要研究方向

 

多肽药物分子设计,多肽药物合成,抗肿瘤多肽药物构效关系、生理药理活性和作用机制研究。

 

成果:

 

    作为项目组主要成员完成了科技部“863”课题一项,兰州大学“985工程”第二批特色研究方向“多肽科学”学科项目建设,兰州大学“985工程”医学子平台建设。主持一项教育部博士点新教师基金、一项甘肃省新药临床前研究重点实验室开放基金和一项兰州大学校内基金;作为第一或主要作者已发表多篇SCI论文,已获国家发明专利授权一项,申请国家发明专利一项,研究工作在国际会议进行报告和墙报展示。

 

 

发表论文

                                                  

1.   锐、张邦治、倪京满,放线菌素D的类似物,国家发明专利,专利号:ZL200410026093.1

 

2. Zhang Bangzhi, Wang KR, Yan JX, Zhang W, Song JJ, Ni JM, Wang Rui* In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides, 2010, 31(4): 568-573 (SCI)

 

3. 张邦治*、王凯荣、王则周、李欣檑、王小丽、倪京满,放线菌素D新类似物的设计、合成与体外抗肿瘤活性研究,高等学校化学学报, 2010, 31(7): 1346-1352 (SCI)

 

4. Zhang W, Li J, Liu LW, Wang KR, Song JJ, Yan JX, Li ZY, Zhang Bangzhi*, Wang Rui* A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice. Peptides, 2010, 31(10): 1832-1838 (SCI)

 

5. Jiang XX, Zhang Bangzhi, Zhang YF, Lin L, Yan WJ, Wang Rui* Direct asymmetric Michael addition of thioether-based aryl sulfanyl-propan-2-one to nitroalkenes catalyzed by a chiral amine-thiourea bifunctional organocatalyst. Chirality. 2010, 22(7): 625–634 (SCI)

 

6. Wang KR, Yan JX, Zhang Bangzhi, Song JJ, Jia PF, Wang Rui* Novel mode of action of polybia-MPI, a novel antimicrobial peptide, in multi-drug resistant leukemic cells. Cancer Lett., 2009, 278, 65-72 (SCI)

 

7. Hong L, Wang L, Chen C, Zhang Bangzhi, Wang Rui* An efficient enantioselective method for asymmetric Friedel-Crafts alkylation of indoles with α,β-unsaturated aldehydes. Adv. Synth. Catal., 2009, 351, 772-778 (SCI)

 

8. Wang KR1, Zhang Bangzhi1, Zhang W, Yan JX, Li J, Wang Rui* Antitumor effects, cell selectivity and structure-activity relationship of a novel antimicrobial peptide polybia-MPI. Peptides, 2008, 29, 963-968 (SCI)

 

9. Wang KR1, Zhang Bangzhi1, Zhang W, Yan JX, Li XL, Wang Rui* Potent antitumor effects of a novel actinomycin D analog Leu5AMD. Cancer Lett., 2008, 268, 38-45 (SCI)

 

10. Chen C, Hong L, Zhang Bangzhi, Wang Rui* Catalytic asymmertric addition of alkynyl zinc reagents to ketones using polymer-supported chiral Schiff-base amino alcohols. Tetrahedron-Asymmetry, 2008, 19, 191-196 (SCI)

 

11. Liu HM1, Zhang Bangzhi1, Liu XF, Wang CL, Ni JM, Wang Rui* Endomorphin-1 analogs with enhanced metabolic stability and systemic analgesic activity: design, synthesis, and pharmacological characterization. Bioorg. Med. Chem., 2007, 15, 1694-1702 (SCI)

12. Wang Q, Zhang BangZhi, Hu GW, Chen C, Zhao QY, Wang Rui* Asymmetric addition of 1-ethynylcyclohexene to both aromatic and heteroaromatic ketones catalyzed by a chiral Schiff base–zinc complex. Org. Biomol. Chem., 2007, 5, 1161-1163 (SCI)

地址:甘肃省兰州市东岗西路199号 邮编:730000
电话:0931-8915098 8915890 电子邮箱:xylcq@lzu.edu.cn