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常民 副教授

【来源:甘肃省新药临床前研究重点实验室 | 发布日期: | 作者: 】     【选择字号:

常民

职务:副教授

电话:0931-8915322

传真:0931-8915322

E-mail:changmin@lzu.edu.cn

科研方向:

1. 多肽生物化学与药物化学                                               

2. 多肽神经生物学                                               

                                                         

个人简历   

常民,男,1975年生,2000年考入兰州大学生命科学学院生物化学与分子生物学专业硕博连读研究生(导师为王锐教授)。于20056月博士毕业,在兰州大学生命科学学院生物化学与分子生物学研究所从事神经肽构效关系,生理、药理学功能及其作用机制等方面的研究。相关的研究成果在SCI期刊上发表。目前主持科研基金项目2项,作为主要参与人参与2项。                                       

 

在研的科研项目                                                       

1. 主持国家自然科学基金一项(30600094),神经肽S的构效关系及其胃肠道生理活性研究,2007.1-2009.12,经费金额22万;                                                       

2. 主持甘肃省科技攻关项目一项,新的神经肽系统在焦虑与抑郁疾病中作用机理的研究,2007.1-2009.12,经费金额3万元。                                                       

  

发表论文  

                                                  

1. Chang M, Li W, Peng YL, Gao YH, Yao J, Han RW, Wang R. Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6]γ2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice. Brain Res. 2009 (SCI, IF2007 = 2.218) 

2. Chang M, Peng YL, Dong SL, Han RW, Li W, Yang DJ, Chen Q, Wang R. Structure-activity studies on different modifications of nociceptin/orphanin FQ: identification of highly potent agonists and antagonists of its receptor. Regul Pept. 2005;130:116-22. (SCI, IF2007 = 2.422) [Times Cited: 9] 

3.Peng YL, Chang M, Dong SL, Li W, Han RW, Fu GX, Chen Q, Wang R. Novel potent agonist [(pF)Phe4,Aib7,Aib11,Arg14,Lys15]N/OFQ-NH2 and antagonist [Nphe1,(pF)Phe4,Aib7,Aib11,Arg14, Lys15]N/OFQ-NH2 of nociceptin/orphanin FQ receptor. Regul Pept. 2006;134:75-81. (SCI, IF2007 = 2.422) [Times Cited: 9]

4. Li W, Chang M, Peng YL, Gao YH, Zhang JN, Han RW, Wang R. Neuropeptide S produces antinociceptive effect at the supraspinal level in mice. Regul Pept. 2009. (SCI, IF2007 = 2.422)

5.Han RW, Chang M, Peng YL, Qiao LY, Yin XQ, Li W, Wang R. Central Neuropeptide S inhibits distal colonic transit through activation of central Neuropeptide S receptor in mice. Peptides. 2009;in press(SCI, IF2007 = 2.368)   

6. Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R. Regulation of Endochondral Ossification by Osteogenic Growth Peptide C-terminal Pentapeptide [OGP(10-14)]. Protein Pept Lett. 2009;in proof. (SCI, IF2007 = 1.097) 

7.Chen ZX, Chang M, Peng YL, Zhao L, Zhan YR, Wang LJ, Wang R. Osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes. Regul Pept. 2007;142(1-2):16-23. (SCI, IF2007 = 2.422) [Times Cited: 2]

8. Han RW, Yin XQ, Chang M, Peng YL, Li W, Wang R. Neuropeptide S facilitates spatial memory and mitigates spatial memory impairment in mice morris water maze. Neuro Lett. 2009;in proof. (SCI, IF2007 = 2.085)

9.Li W, Gao YH, Chang M, Peng YL, Yao J, Han RW, Wang R. Neuropeptide S inhibits the acquisition and the expression of conditioned place preference to morphine in mice. Peptides. 2009;30(2):234-40. (SCI, IF2007 = 2.368)

地址:甘肃省兰州市东岗西路199号 邮编:730000
电话:0931-8915098 8915890 电子邮箱:xylcq@lzu.edu.cn